Bicyclic phosphorus compounds

ABSTRACT

Esters of 4-hydroxymethyl-1-phospha-2,6,7trioxabicyclo(2,2,2)octan and p-hydroxyphenylcarboxylic acids are stabilisers for organic materials. They are prepared by reacting the 4-hydroxymethyl-1-phospha-2,6,7-trioxabicyclo(2,2,2)octan with a corresponding p-hydroxymethylcarboxylic acid.

' United States Patent [1 1 Schwarzenbach et al.

[ Dec. 16, 1975 BICYCLIC PHOSPHORUS COMPOUNDS Inventors: Kurt Schwarzenbach, Aesch;

Siegfried Rosenberger, Riehen, both of Switzerland Assignee: Ciba-Geigy Corporation, Ardsley,

Filed: Sept. 21, 1973 Appl. No.: 399,787

Foreign Application Priority Data Sept. 26, 1972 Switzerland 14119/72 US. Cl. 260/937; 106/15 FP; 252/400 A; 260/45.7 P; 260/45.7 PS; 260/212;

Int. Cl. C07F 9/15; C08K 5/53 [58] Field of Search 260/9 37 [56] References Cited UNITED STATES PATENTS 3,168,549 2/1965 Ratz 260/937 3,808,296 4/1974 Brunetti 260/937 X Primary Examiner-Anton H. Sutto Attorney, Agent, or FirmLuther A. R. Hall 12 Claims, No Drawings '1 2 BICYCLIC PHOSPHORUS COMPOUNDS 7 denotes y gmQ denOteS O. H, H CO', OCO- or NHCONH, Y denotes The present invention relates 'to new compounds, -1, their manufacture and their use for stabilising organic material. j C|H It is known to employ derivatives of sterically hin- 1: dered phenols as stabilisers for plastics against thermooxidative or light-induced degradation. It is furtherof -(ClI -S(Cl-l 1 denotes l or 2, Z denotes more known to p y PhO$PhOru$ CmP0undS as oxygen or sulphur, n denotes O to 4 and p and q indestabilisers conjointly with phenolic antioxidants for pendently f one another denote O or 1. stabilising purposes, and such mixtures frequently sho Particularly preferred compounds of the formula I a synergistic effect. It is also known to employ bicyclic are those wherein R and R denote tert.butyl, R dephosphite'syin which the phosphorus represents the notes hydrogen. Q denotes O. NH, -NH- bridgehead atom, as phosphorus compounds in such CO-, OCO or NHCONH-, Y denotes mixtures. CH or -(CH -SCH Z denotes oxygen. It has now been found, surprisingly, that the new n denotes O to 4 and p and q independently of one compounds of the general formula I another denote O or 1.

l i CH 0 (I) HO C l-l Q (Y)p -OCH -C-CH OP-(Z)q R CH 0 wherein R denotes alkyl with 1 5 carbon atoms, Amongst the preferred compounds there should cycloalkyl with 6 8 carbon atoms or aralkyl with 7 above all be mentioned the following classes:

tart. .Butyl 0 r()\ l HO C H -NH- O-CH -C P- (Z) n 2n 2 q (Ia) tert.Butyl 9 carbon atoms, R denotes hydrogen, alkyl with l 5 in which n denotes O to 4, Z denotes oxygen or sulphur carbon atoms, cycloalkyl with 6 8 carbon atoms, or and q denotes O or 1.

,R l i O HO C H -COO-(CH -S-(Cl-l -8-O-CH -C P (Ib) n 2n 2 2 2 z 2 aralkyl with 7 9 carbon atoms, R denotes hydrogen in which R denotes methyl, isopropyl or tert.butyl, R or methyl, Q denotes -O, -NH, NHCO, denotes hydrogen, methyl, isopropyl or tert.butyl, n

1 Z l I a no 0411-1 -c o-cn P x denotes l 5 and y and 1 independently of one another denote or 2 Z denotes oxygen orgsulphurr n in which R denotes methyl, isopropyl or tert.butyl and denotes 0 to 5 and p and q independently of one R denotes hydrogen, methyl, isopropyl or tert.butyl. other denote O or are stabilisers of substantially better action than theac'tion of the abovement ioned synergis- 1 O tic mixtures of phenolic'antioxidants'w th compounds 5 o 0 containing'phosphoi'usff H H g g Preferred compounds of the formula I fare those n Zn 2 wherein R denotes methyl, isopropylor't ertbutyl, R denotes hydrogen, methyl, isopropyl or tertbutyl, R 2

in which R denotes methyl, isopropyl or tert.b.utyl, R denotes hydrogen, methyl, isopropyl or tert.butyl, A denotes O-- or --NI-land n denotes 0 or 1.

acid l-phospha-2,6,7-trioxabicyclo-[2,2,2]-oct-4-ylmethyl ester.

Compounds of the formula I can be manufactured to 't.Butyl 0 0 0 n n JIO- 0 (NH) -C-NH-CH -C-O-Cll -C (18) tert.Butyl in which m denotes O or 1.

If Y in the formula I is a C,I-I radical. it can be quite generally by reaction of 1 mol of a compoundof the formula [I no c n -q- (Y)pCOCl R? vR Or If Y in the formula 1 denotes a C,I-I, radical, it can be CH=CI-I or If Y denotes (CH S(CH it can be, for example, the radical -CI-I -S-CH or CH- SCI-I -CH Y can also be an o-, mor p-phenylene radical or a 1,2-, l,3- or 1,4-cyclohexylene radical.

Examples of compounds of the formula I are: 3,5Ditert.butyl-4-hydroxyphenyl-carbamic acid 1- phospha-2,6,7-trioxabicyclo-[2,2,2]-oct-4-yl-methyl ester, 2- 3-( 3 ,5ditert.butyl-4-hydroxyphenyl )propionyloxy]-ethylmercaptoacetic acid 1-phospha-2,6,7- trioxabicyclo-[2,2,2]-oct-4-yl-methyl ester, 2-(3,5- ditert.butyl-4-hydroxy-benzoyloxy)-ethylmercaptopropionic acid I-phospha-2,6.7-trioxabicyclo-[2,2,2]-oct- 4-yl-methyl ester, 2-[3-(3-tert.butyl-4-hydroxy-5- methylphenyl )-propionylo xy -ethylmerc aptoacetic acid l-phospha-2,6,7-trioxabicyclo-[ 2 ,2,2 -oct-4-ylmethyl ester, 2-[3-tert.butyl-4-hydroxyphenyl)propionyloxy]-ethylmercaptoacetic acid l-phospha-2,6,7- trioxabicyclo-[2,2,2]-oct-4-yl-methyl ester, 3,5-ditert- .butyl-4-hydroxyphenoxy-acetic acid 1-phospha-2,6,7- trioxabicyclo-[2,2,2]-oct-4-yl-methyl ester, 3-tert.butyl-4-hydroxyphenoxyacetic acid l-phospha-2,6,7-trioxabicyclo-[2,2,2]-oct-4-yl-methyl ester, oxalic acid l-phospha-2 ,6,7-trioxabicyclo- 2 ,2,2 -oct-4-'yl'-methyl' ester-3,5-ditert.butyl-4-hydroxyanilide, oxalic acid 1- phospha-2,6,7-trioxabicyclo-[2,2,2]-oct-4-yl-methyl ester -3,5-diisopropyl-4-hydroxyanilide, oxalic acid 65 l-phospha-2,6,7-trioxabicyclo-[2,2,2]-oct-4-yl-methyl ester-3-tert.butyl-4-hydroxy-5-methylanilide' and 3 ,5- ditert.butyl-4-hydroxyphenyl-carbamoylaminoacetic with 1 mol of a compound of the formula III in the presence of a base for neutralising the hydrochlo ric acid produced. I

This process, for example, is particularly successfu for obtaining the compounds of the formula Ic.

A further manufacturing process consists of the reac tion of 1 mol of a compound of the formula IV wherein R denotes a lower alkyl group, preferably methyl or ethyl, with 1 mol of a compound of the formula III in the presence of catalytic amounts of a basic catalyst. In this reaction, 1 mol of R Ol-l is eliminated. Examples of basic catalysts which are used are alkali metal amides such as sodium amide or lithium amide, alkali metal hydroxides such as lithium hydroxide, sodiumhydroxide or potassium hydroxide, alcoholates such as the sodium and magnesium alcoholates of methanol, ethanol or tertbutanol or tertiary amines such as triethylamine. Preferred basic catalysts are sodium methylate, sodium hydride and lithium amide.

This process is preferentially used for the manufacture of the compounds of the formula Ic, Id and le.

. The compounds of the formula I, in which Q denotes 1 a compound of the formula NH and p denotes zero, can also be manufactured by the reaction of 1 mol of a compound of the general formula V i v with 1 mol of a compound of the formula III.

The reaction can be carried out in an aliphatic or aromatic hydrocarbon such as benzine of defined boil- 1 5 ing range, benzene, toluene or xylene as the solvent. Preferably, no solvent is used.

The compounds of the formula Ia can be manufactured in this way.

The compounds of the formula lb can advantageously be manufactured by reaction of a mercaptan of the formula HO -C ll -COO- (CH -SH with the chloroacetic acid ester or acrylic acid ester of the formulae 0 H l ClcH,-C-0-CH -c-o-P The starting compounds for the manufacture of the compounds la, Ib, Ic, Id and le are known in some tert.l3utyl 110 O C H -NH tert.Butyl with phosgene. The amines of the formula Va wherein n denotes 0 or 1 are known. Compounds of the formula Va wherein n denotes 2 to 4 am obtained by reaction of 6 tert.Butyl no ca x,

tert.l3utyl wherein X denotes a halogen atom, a

alkyl alkyl group or group, with a nitro compound of the formula (nl) (2n1)' 2 optionally in the presence of a basic catalyst, with subsequent reduction with zinc or hydrogen. The starting compounds of the formula R o 0 H0 c s al-@021 2 required for the manufacture of the compounds of the formula Id, wherein R denotes lower alkyl, are obtained by reaction of a compound of the formula .H()- -C H --A-H n 0 1) R r with an oxalic acid monoalkyl ester chloride of the formula in the presence of a base for binding the hydrochloric acid liberated.

The starting compounds of the formula .tert.Butyl required for the manufacture of the compounds of the formula le. wherein R denotes lower alkyl, are obtained by reaction of a compound of the formulae tert.Butyl tert .Butyl with an ester of glycine. of the formula H l lCH- ,COOR

The compounds of the formula I are used as stabilisers for organic substrates. As such it is possible to use. for example:

1. Polymers which are derived from hydrocarbons with single or double unsaturation, such as polyolefines, such as, for example polyethylene. which can optionally be crosslinked. polypropylene, polyisobutylene. polymethylbutene- 1, polymethylpentenel polybutene-l, polyisoprene, polybutadiene, polystyrene, polyisobutylene, copolymers of the monomers on which the homopolymers mentioned are based, such as ethylenepropylene copolymers., propylene-butene-l copolymers, propylene-isobutylene copolymers, styrene-butadiene copolymers and terpolymers of ehtylene and propylene with a diene, such as, for example, hexadiene, dicyclopentadiene or ethylidenenorbornene; mixtures of the abovementioned homopolymers, such as, for example, mixtures of polypropylene and polyethylene, polypropylene and polybutene-l, or polypropylene and polyisobutylene.

2. Vinyl polymers containing halogen, such as polyvinyl chloride, polyvinylidene chloride, polyvinyl fluoride, but also polychloroprene and chlorinated rubbers.

3. Polymers which are derived from a,B-unsaturated acids and their derivatives, such; as polyacrylates and polymethacrylates, polyacrylamides and polyacryloni-' trile, as well as their copolymers with other vinyl compounds, such as acrylonitrile/butadiene/styrene, acrylonitrile/styrene and acrylonitrile/styrene/acrylic ester copolymers.

4. Polymers which are derived from unsaturated alcohols and amines or their acyl derivatives or acetals, such as polyvinyl alcohol, polyvinyl acetate, polyvinyl stearate, polyvinyl benzoate, polyvinylmaleate, polyvinyl butyral, polyallyl phthalate, polyallyl melamine and their copolymers with other vinyl compounds, such as ethylene/vinyl acetate copolymers.

5. Homopolymers and copolymers which are derived from epoxides, such as polyethylene oxide or the polymers which are derived from bis-glycidyl ethers.

6. Polyacetals, such as polyoxymethylene and polyoxyethylene, as well as those polyoxymethylenes which contain ethylene oxide as the comonomer.

7. Polyphenylene oxides.

8. Polyurethanes and polyureas.

9. Polycarbonates. A

10. Polysulphones.

l 1. Polyamides and copolyamides which are derived from diamines and dicarboxylic acids and/or from aminocarboxylic acids or the corresponding lactams, such as polyamide 6, polyamide 6/6, polyamide16/l0, polyamide 11 and polyamide 12.

12. Polyesters which are derived from dicarboxylic acids and dialcohols and/or from hydroxycarboxylic xample,

8 acids or the corresponding lactones. such as polyethylenc glycol terephthalate or poly-l .4-dimethylolcyclohexane tercphthalate.

l3. Crosslinked polymers which are derived from aldehydes on the one hand and phenols. ureas and melamines on the other. such as phenol-formaldehyde, urea-formaldehyde and melamine-formaldehyde resms. i

l4. Alkyd resins. such as glyccrinc-phthalic acid resins and their mixtures with melamine-formaldehyde resins.

l5. Unsaturated polyester resins which are derived from copolyestersof saturated and unsaturated dicarboxylic acids with polyhydricalcohols, with vinyl compounds as crosslinking agents, and also their halogencontaining modifications of low inflammability.

16. Natural polymersjsuch as cellulose. rubber, proteins and their polymer-homologously chemically modified :derivatives. such as cellulose acetates. cellulose propionatesand cellulose butyrates, or the cellulose ethers. such as methylcellulose.

17. High molecular monomeric substances, for example mineral oils. animal and vegetable fats, oils and waxes. or oils, waxes and fats based on synthetic esters.

The compounds of the formula I are incorporated into the substrates in a concentration of 0.01 to 5% by weight calculated relative to the material to be stabilised.

Preferably, 0.05 to 2.0, and particularly preferentially 0.1 to 1.0,% by weight of the compounds, calculatedrelative to the material to be stabilised, are incorporated into the latter. The incorporation can take place before or during shaping, for example by mixing in at least one of the compounds of the formula I and optionally further additives according to the methods customary in the art, or by applying the dissolved or dispersed compounds to the polymer, if appropriate wth subsequent evaporation of the solvent.

In the case of crosslinked polyethylene, the compounds are added before crosslinking.

The compounds of the formula I can also be added before or during polymerisation, and possible incorporation into thepolymer chain results in stabilised substrates in which the stabilisers are not volatile or extractable.

As further additives together with which the stabilisers can be employed, there should be mentioned:

1. Antioxidants of the hydroxyaryl series, such as, for example;

A. Simple 2,6-dialkylphenols such as, for example, 2,6-ditert.butyl-4-methylphenol, 2-tert.butyl-4,6-dimethylphenol,' 2,6-ditert.butyl-'4-methoxymethylphenol and 2,6-dioctadecyl-4-methylphenol.

B. Derivatives of alkylated hydroquinones such as, for example, 2,5-ditert.butyl-hydroquinone, 2,5-ditert- .amyl-hydroquinone, 2,6-ditert.butyl-hydroquinone, 2,5-ditert.butyl-4-hydroxy-anisole, 3,5-ditert.butyl-4- hydroxy-a nisole, tris-( 3 ,5 -ditert. butyl-4-hydroxyphenyl)- .phosphite, 3,5-ditert.butyl-4-hydroxyphenylstearate and di-( 3,5-ditert.butyl-4-hydroxyphenyl)-adipate.

C. Hydroxylated thiodiphenyl ethers such as, for 2,2 '-thiobis-( o-tert.butyl-4-methylphenol 2,2 -thiobis-( 4 octylphenol 4,4"-thiobis-( 6-tert.butyl- 3-inethylphendl 4,4 .-thiobis-( 3,6-di-sec.amylphenol 4,4-thiob'is-(6-tert.butyl-Z-methylphenol) and 4,4- bis( 2,6-dimethyl-4-hydroxyphenyl )-disulphide.

111 benzophenone, 2-hydroxy-4-benzyloxybenzophenone, 2,4,2,4-tetrahydroxy-benzophenone or 2,2-dihydroxy-4,4 -dimethoxy-benzophenone.

d. l,3-Bis-(2'-hydroxy-benzoyl)-benzenes, for example l,3-bis-(2-hydroxy-4-hexyloxy-benzoyl)-benzenc, 1,3-bis-( 2 -hydroxy-4'-octoxy-benzoyl)-benzene. and 1,3-bis-( 2 -hydroxy-4-dodecyloxy-benzoyl )-benzene.

e. Aryl esters of optionally substituted benzoic acids such as, for example, phenyl salicylate, octylphenyl salicylate, di-benzoylresorcinol, bis-(4-tert.butylbenzoyl)-resorcinol, benzoylresorcinol and 3,5-di-tert.butyl-4-hydroxybenzoic acid 2,4-di-tert.butyl-phenyl ester, octadecyl ester of 2-methyl-4,6-di-tert.butyl-phenyl ester.

f. Acrylates, for example oz-cyano-B,B-diphenylacrylic acid ethyl ester or isooctyl ester, a-carbomethoxycinnamic acid methyl ester, a-cyano-,Bmethyl-pmethoxy-cinnamic acid methyl ester or butyl ester and N-( B-carbomethoxy-vinyl )-2-methyl-indoline.

g. Nickel compounds, for example nickel complexes of 2,2-thiobis-(4-tert.octy1phenol), such as the 1:1 and 1:2 complex, optionally with other ligands such as nbutylamine, nickel complexes of bis-(4-tert.octylphenyl)-sulphone, such as the 2:1 complex, optionally with other ligands such as 2-ethylcaproic acid, nickel dibutyldithiocarbamate, nickel salts of 4-hydroxy-3,5- di-tert.butylbenZyl-phosphonic acid monoalkyl esters such as the methyl, ethyl or butyl ester, the nickel complex of 2-hydroxy-4-methyl-phenyl-undecylketonoxime and nickel 3,5-ditert.butyl-4-hydroxy-benzoate.

h. Oxalic acid diamides, for example 4,4-di-octyloxy anilide, 2,2 '-di-octyloxy-5 ,5 'di-tert.butyl-oxanilide, 2,2'-di-dodecyloxy-5 ,5 -di-tert.butyl-oxanilide, 2- ethoxy-5-tert.butyl-2'-ethyl-oxanilide, 2-ethoxy-2ethyl-oxanilide, N,N'-bis-( 3-dimethylaminopropyl )oxalamide, mixtures of o-and p-methoxyand oand pethoxy-di-substituted oxanilides and mixtures of 2- ethoxy-5-tert.butyl-2'-ethyl-oxanilide with 2-ethoxy-2'- ethyl-4,4'-di-tert.butyl-oxanilide.

3. Metal deactivators, such as oxanilide, isophthalic acid dihydrazide, sebacic acid bis-phenylhydrazide, bis-benzylideneoxalic acid dihydrazide, N,N-diacetyladipic acid dihydrazide, N,N'-bis-salicyloyl-oxalic acid dihydrazide, N,N-bis-salicyloyl-hydrazine and N,N- bis-( 3 ,5-ditert.butyl-4-hyd roxyphenyl-propionyl hydrazine.

4. Phosphates, such as triphenylphosphite, diphenylalkylphosphites, phenyldialkylphosphites, trinonylphenylphosphite, trilaurylphosphite, trioctadecylphosphite, 3,9-di-isodecyloxy-2,4,8, -tetraoxa-3,9- diphosphaspiro-(5,5)-undecane and tri-(4-hydroxy- 3,5-di-tert.butylphenyl )-phosphite.

5. Compounds which destroy peroxides, such as esters of B-thiodipropionic acid, for example the lauryl, stearyl, myrystyl or tridecyl esters, salts of 2-mercaptobenzimidazole, for example the zinc salt, and diphenylthiourea for polyolefines.

6. Polyamide stabilisers, such as copper salts in combination with iodides and/or further phosphorus compounds and salts of divalent manganese.

7. Basic co-stabilisers, such as polyvinyl pyrrolidone, melamine, benzoguanamine, triallyl-cyanurate, dicyandiamide, urea derivatives, hydrazine derivatives, amines, polyamides, polyurethanes, and alkali metal salts and alkaline earth metal salts of higher saturated or unsaturated fatty acids such as, for example, the laurates, myristates, palmitates, stearates, oleates or ricinoleatcs of calcium, magnesium, zinc, sodium or potassium. Such salts are advantageously added to the 12 stabiliser according to the invention. in concentrations of 0.1 to by weight, preferably 30-60% by weight, prior to incorporation into the material to be protected.

8. PVC stabilisers such as organic tin compounds, organic lead compounds and Ba/Cd salts of fatty acids.

9. Nucleating agents, such as 4-tert.butylbenzoic acid, adipic acid and diphenylacetic acid.

10. Other additives such as plasticisers. lubricants for example glycerine monostearate. emulsifiers, antistatic agents, flameproofing agents, pigments, carbon black, asbestos, glass fibres, kaolin and tale.

The invention is explained in more detail in the examples which follow. Per cent (7:) in the examples denotes per cent by weight and parts in the examples denote parts by weight.

EXAMPLE 1 tertJZuty].

tert .Butyl H3 1st Step 106 g of N,N-dimethyl(3,5-di-tert.butyl-4-hydroxybenzyl)amine and 400 ml of 2-nitropropane are heated to 110C for 8 hours. The orange-coloured solution is concentrated in vacuo, mixed with 70 ml of petroleum ether and cooled. l-(3,5-Di-tert.butyl-4- hydroxybenzyl)-2-nitropropane crystallises out on cooling. It has a melting point of C. 2nd Step 92 g of 2-(3,S-di-tert.butyl-4-hydroxybenzyl)-2- nitropropane, 500 ml of glacial acetic acid, 400 ml of concentrated hydrochloric acid, 900 ml of water and 78g of zinc dust are mixed and the mixture is heated to 100C for 5 /2 hours. The solution is filtered hot and then cooled to room temperature. The hydrochloride of 2-(3,5-di-tert.butyl-4-hydroxybenzyl)-2-aminopropane precipitates slowly. The crystals are filtered off and boiled once with 500 ml of 20% strength hydrochloric acid, and then dried. The product sublimes at temperatures above 200C.

To prepare the free amine, the hydrochloride is dissolved in a large amount of boiling water and the solution is filtered hot and subsequently treated with concentrated aqueous ammonia. The 2-(3,5-di-tert.butyl- 4-hydroxybenzyl)-2-aminopropane which has precipitated is filtered off and dried. It has a melting point of EXAMPLE 2 0 eu o I 8.2 g of 4-hydroxymethyl-1-phospha-2,6,7-trioxabicyclo-[2,2,2]-octane are dissolved in 70 ml of acetone. After adding 5.0 g of triethylamine, 5.8 g of chloroacetyl chloride are added dropwise at room temperatures over the course of 10 minutes. The mixture is stirred for one hour at room temperature and then filtered and evaporated. A viscous oil remains, which is chloroacetic acid l-phospha-2,6,7-trioxabicyclo- [2,2,2]-oct-4-yl-methyl ester.

13 14 7 EXAMPLE 3 EXAMPLE 6 tert.Buliyl tert.Butyl HO Dill-C a g 2 5 no 0 comma -coocn tert: .But 1 text .Butyl 11.1 g of 2,6-di-tert.butyl-hydroquinone are dissolved in 100 ml of dimethylacetamide. After adding 25 g of glycine methyl ester are first taken and 5.0 g 4.0 g of pyridine, 6.8 g of oxalic acid monoethy1 ester of 3,S-di-tert.butyl-4-hydroxybenzoyl chloride are chloride are added dropwise over thecourse of added in portions whilst stirring. The mixture is stirred minutes at room temperature. The mixture is stirred for for one hour and then diluted with 200 ml of ether. The 1 hour at 80C and then poured into 700 m1 of ice 15 ether solution is extracted by shaking with dilute hydrowater. The organic material is extracted with ether. chloric acid and then evaporated. On addition of cyclo- After evaporation of the ether solution, a yellow oil hexane, the product crystallises. N-(3,5-Di-tert.butylremains, which slowly crystallises. After recrystallisa- 4-hydroxybenzoyl)-aminoacetic acid methyl ester of tion from a mixture of 50 ml of methanol and 8 ml of melting point ll6l 18C is thus obtained. water, oxalic acid 3,5-di-tert;butyl-4-hydroxyphenyl 20 ester/ethyl ester of melting point 6061C is obtained. EXAMPLE 7 EXAMPLE 4 tert .Butyl tart -Butyl o I l] ,1} no NH no CH -NH -C-()C2H5 -C-NH-CH -C I i OCH tert.Butyl 3 tert.)3utyl 9.0 g of 3,5-di-tert.butyl-4-hydroxy-benzylamine are 12.3 g of iert-butyl-4-hydroxphenyli y n suspended in 60 ml of methylene chloride. A solution are dissolved in 100 ml of ligroin. 4.4 g of glycine of 5.3 g of oxalic acid monoethy1 ester chloride in m1 methyl ester are added dropwise to the solution at of methylene chloride is added dropwise to the mixture room temperature. The product first separates out as at below 30C. After adding 3,1 g f idi h i 35 an oil and becomes crystalline after stirring the mixture ture is boiled for4hours. The methylene chloride soluat for 0116 hOUf- After g. the miXture is tion is washed with dilute sodium hydroxide solution filtered and the product recrystallised from toluene. and then with dilute hydrochloric acid, and evaporated. 3,S-Di-tert.butyl-4-hydroxyphenyl-carbamoyl-aminoa- The oxalic acid monoethy1 ester 3 ,5-di-tert.butyl-4- hydroxybenzyl-amide which remains melts at 143C cetic acid methyl ester of melting point 195C is thus obtained.

after recrystallisation form cyclohexane. EXAMPLE 8 tort .But 1 3 y 011 0 I l l /-0 no O -'c1a -c-Aa-c-o-ca -c P 3 tert Butyl EXAMPLE 5 29 g of 2-(3,5-di-tert.butyl-4-hydroxybenzyl)-2- aminopropane are dissolved in 400 ml of toluene. A tart O 0 slow stream of phosgene is passed into the solution, a: ll which is heated to the boil, for 6 hours. The solution is no z evaporated in vacuo. The crude 2-(3,5-di-tert.butyl-4- hydroxyphenyl)- l l-dimethyl-ethylisocyanate which y remains is used in situ for the next stage 16.4 g of 4-hydroxymethyl-1-phospha-2 ,6,7-trioxabicyclo- 1L8 g of 3,'5 di tert buty] 4 hydr0xy benzy1 alcohol [2,2,2]-octane are added and the resulting mixture is are dissolved in 100 ml of dimethylacetamide. 6.8 g of heated to 1 whilst Stirringoxalic acid monethyl ester chloride are added dropwise over the course of 15 minutes at room temperature. O li a glassy substance r lt f whi h the The mixture is stirred for one hour at 50C and' infrared spectrum agrees with the structure of 1,1- poured into 500 ml of ice water. The product which has di th 1-2-( 3,S-di-tert,butyl-4-hydroxyphenyl)-ethylseparated out crystallises slowly. The solid is filtered ba i id 1- h h -2,6,7-t -i bicyclo [2,2,2]- orf, dried and recrystallised from hexane. Oxalic acid t-4 l h l ester- 3,5-di-tert.butyl-4-hydroxybenzyl ester/ethyl ester of (st bili N 1) mel ing p n v '6 is s ain P: Calculated-z 6.50% found: 6.34%

15 EXAMPLE 9 tert ."Butyl O EXAMPLE l tert.13utyl Cll CH -COO-CH CH tert.]3utyl 17 g of B mercaptoethyl-3-(3,5-di-tert.butyl-4- hydroxyphenyl)-propionate and 12.0 g of 4-hydroxymethyll -phospha-2,6,7-trioxabicyclo- 2,2,2]-octane chloroacetate are first introduced into 100 ml of absolute ethanol under nitrogen. A solution of 2.7 g of potassium hydroxide in ml of ethanol is added dropwise at room temperature. When the exothermic reaction has subsided, the mixture is filtered and the filtrate is evaporated. The product is isolated from the residue by column chromatography, eluting with a mixture of toluene and methanol 1:1 The resulting 2-[3-( 3,5-ditert.-butyl-4-hydroxyphenyl )propionyloxyl ]-ethylmercaptoacetic acid l-phospha-Z,6,7-trioxa-bicyclo- [2,2,2]-oct-4-yl-methyl ester is a light yellow, viscous liquid. (stabiliser (Stabiliser 3): P: Calculated: 5.7% found: 5.4%

EXAMPLE 1 1 11 OCH -C-O-CH so terLButyl 8.2 g of 4-hydroxymethyl-1-phospha-2,6,7-trioxabicyclo-[2.2.2]-octane are dissolved in 50 ml of dimethylacetamide. A solution of 16.5 g of 3,5-di-tert.butyl-4-hydroxyphenoxyacetyl chloride in 50 ml of dimethylacetamide is added dropwise with vigorous stirring, in the course of which the temperature rises to 40C. The mixture is stirred for one hour at C, cooled and poured into 2 liters of water. The product which in part is obtained in a crystalline form is extracted with ether and the ether phase is dried and evaporated. The solid which remains is recrystallised from alcohol. 3,5-Di-tert.-butyl-4-hydroxyphenoxyacetic acid l-phospha-2,6,7-trioxabicyclo-[2,2,2l-oct- 4-yl-methyl ester, (stabiliser No. 4) of melting point 142C is thus obtained.

16 If, in this example. the 3,5-di-tertbutyl-4 -hydroxyphenoxy-acetyl chloride is replaced by an equimolecular amount of 3-tert.butyl-4-hydroxy-S-methylphenoxyacetyl chloride and otherwise the same procedure is followed. 3-tert.butyl-4-hydroxy-S-methylphenoxyacetic acid l-phospha-2,6,7-trioxabicyclo-[2.2,2]oct- 4-yl-methyl ester is obtained.

EXAMPLE 12 tert .Butyl 16 g of oxalic acid monoethyl ester 3,5-di-tert.butyl- 4-hydroxy-anilide and 10 g of 4-hydroxymethyl-l-phospha-2,6,7-trioxabicyclo-[2,2,2]-octane are first introduced into 50 ml of diethylene glycol dimethyl ether. After adding 0.4 g of sodium methylate, the mixture is heated to C for 2 hours. After cooling, it is poured into 700 ml of water. the product which has separated out is extracted with ether and the ether solution is dried and evaporated. The residue is dissolved in a little hot alcohol and hexane is added to the solution, whereupon the crystallisation starts. For further purification, the product is again recrystallised from carbon tetrachloride and subsequently stirred with boiling cyclohexane, filtered off and dried. Oxalic acid l-phospha- 2,6,7-trioxabicyclo-[2,2,2]-oct-4-yl-methyl ester 3,5- di-tert.butyl-4-hydroxyanilide of melting point 211C (Stabiliser No. 6) is thus obtained.

If, in this example, the oxalic acid monoethyl ester 3,S-di-tert.butyl-4-hydroxy-anilide is replaced by an equimolecular amount of oxalic acid monoethyl ester (3,5-di-tert.butyl-4-hydroxybenzyl)-amide, and otherwise the same procedure is followed, oxalic acid 1- phospha-2,6,7-trioxabicyclo-[2,2,2l-oct-4-yl-methyl ester 3,5-di-tert.butyl-4-hydroxybenzylamide is obtained.

If, in this example, the oxalic acid monoethyl ester 3,5-di-tert.butyl-4-hydroxy-anilide is replaced by an equimolecular amount of N-(3,5-di-tert.butyl-4- hydroxybenzoyl)aminoacetic acid methyl ester and otherwise the same procedure is followed, 3,5-di-tert- .butyl-4-hydroxybenzoyl-aminoacetic acid l-phospha- 2,6,7-trioxabicyclo-[2,2,2]-oct-4-yl-methyl ester is obtained.

If, in this example, the oxalic acid monoethyl ester 3,5-di-tert.butyl-4-hydroxyanilide is replaced by an equimolecular amount of 3,5-di-tert.butyl-4-hydroxyphenylcarbamoyl-aminoacetic acid metyl ester, and otherwise the same procedure is followed, 3,5-di-tert- .butyl-4-hydroxyphenylcarbamoyl-aminoacetic acid 1 -phosph a-2 ,6,7-trioxabicyclo- 2 ,2,2 -oct-4-yl-methyl ester (Stabiliser No. 5) of melting point 250C is obtained. The product is isolated from the reaction mixture by column chromatography on silica gel G (Merck). A mixture of 98% of toluene and 2% of methanol is used as the eluting agent. The product is preferentially eluted, before the starting material.

EXAMPLE 13 tert.Butyl 0 F H0- 0 will-own --c -P tert.l utyl 9.0 g of oxalic acid 3,5-di-tert.butyl-4-hydroxybenzyl ester/ethyl ester and 4.4 g of 4-hydroxymethyl-1-phospha-2,6,7-trioxabicyclo-[2,2,2]-octane are heated to 60C, whereby a homogeneous melt is produced. After adding 0. 1 g of sodium methylate. the reaction vessel is evacuated and the temperature is brought to 100C. After one hour the mixture is cooled, whereupon the product solidifies to a glass. It can be powdered and then melts at approx. 80C. Oxalic acid 3,5-di tert.butyl-4-hyd roxy-benzyl ester/ 1 -phospha-2,6,7-trioxabicyc1o-[2,2,2 ]-oct-4-methyl ester is thus obtained. (Stabiliser No. 7).

P: Calculated: 6.8% found: 6.5%

If. in this example, the oxalic acid 3,5-di-'tert.butyl-4- hydroxybenzyl-ethyl ester is replaced by an equimolecular amount of oxalic acid 3,5-di-tert.butyl-4-hydroxyphenyl ester/ethyl ester and otherwise the same procedure is followed, oxalic acid 3,5-di-tert.butyl-4-hydroxyphenyl ester/ 1 -phospha-2,6,7-trioxabicyclo-[2,2,2]- oct-4-yl-methyl ester is obtained.

EXAMPLE 14 tert: .Butyl 0 1-10 NH 3 o c r o tert .Butyl EXAMPLE l tert.But:yl

tert.13utyl 40 g of 3,5-di-tert.butyl-4-hydroxyphenyl-carbamic acid 1-phospha-2,6,7-trioxabicyclo-[2,2,2] oct-4-ylmethyl ester are boiled with 3.2 g of sulphur and 0.2 g of sodium sulphide in 100 ml of toluenerfor..4 hours Stabi- EXAMPLE 16 The additives listed in Table l are sprinkled dry, at a concentration of 0.5% onto dried po1yamide-6 granules (relative viscosity 2.9, 1% in concentrated sulphuric acid) and the sprinkle-coated mixtures are re granulated on a single-screw extruder at 260C. 0.3 mm thick pressed films are then produced from the granules, again at 260C, and 1 cm wide test strips are punched from these pressed films. The activity of the additives added to the test specimens is tested by heat aging in a circulating air oven at 165C. The thermooxidative degradation of the material during heat aging is followed by periodically measuring the relative viscosity of a 1% strength solution in 96% strength sulphuric acid, determining the time after which the relative viscosity decreases from 2.9 to a value of 2.0 (Table 1).

Table 1 Heat aging time at 165C for the relative solution viscosities to decrease from 2.9

Stabiliser No. to 2.0. in hours No additive 5 4 45 EXAMPLE 1 7 tested by heat aging in a circulating air oven at C and 149C, using an additive-free test strip for comparison. 3 test strips of each formulation are employed for this test. The incipient, easily visible decomposition of the test strip is defined as the end point. Theresults are given in days.

Table 2 Days to reach incipient decomposition Stabiliser No. 149C 135C No additive /2 l 2 23 89 4 15 98 v 6 20 86 EXAMPLE 18 The test specimens described in Example 17 were Table 3 Colour assessment according to scale 1 After incorpora After Boiling water. Stabiliser No. tion exposure 1 week EXAMPLE 19 100 parts of polypropylene (melt index 3.2 g/ 10 minutes, 230C/2,l60 g) are thoroughly mixed for 10 minutes in a shaking apparatus with 0.1 part of one of the additives listed in Table 4 below and 0.3 part of dilauryl thiodipropionate.

The resulting mixture is kneaded for 10 minutes in a Brabender plastograph at 200C and the mixture thus obtained is subsequently pressed in a sheet press at 260C platen temperature to give 1 mm thick sheets from which strips 1 cm wide and 17 cm long are punched.

The activity of the additives added to the test strips is tested by heat aging in a circulating air oven at 135C and 149C, using for comparison a test strip which only contains 0.3 part of dilauryl thiodipropionate. Three test strips of each formulation are employed for this test. The incipient, easily visible decomposition of the test strip is defined as the end point and the results are quoted in days.

0.25 part of one of the additives of Table 5 is dissolved in 100 parts of a cold strength polyurethane solution (ESTANE 5707 of Messrs. Goodrich).

Approx. 400 ,u. thick films of these solutions are spread on a glass plate by means of a film spreader and these dry, after approx. 10 minutes drying in circulating air at 140C, to give films of final thickness 100 ,u. Accordingly, the stabilisers are present in the films in a concentration of 1.0%. Samples of these films are exposed in a Xenotest instrument, against a white cardboard background, until incipient visually perceptible yellowing is reached. The results in Table 5 are given in hours.

Table 5 Exposure time in the Xenotest instrument. to reach distinctly visible yellowing stabiliser No. (in hours) Notes No additive 100 As can be seen from Table 5, stabiliser 4 according to the invention provides excellent protection against yellowing of polyurethane films, both when used alone and when used with co-additives.

EXAMPLE 21 Protection of polyacrylonitrile (PAN) against yellow- 0.5 part of stabiliser 4 and 25 parts of PAN are dissolved in parts of dimethylformamide (DMF) at 70C over the course of 4 hours. On visual comparison, the stabilised solution already shows a distinctly lighter colour than the solution without additive. Approx. 500 [1. thick films of these solutions are spread on a glass plate and dried at 125C for 10 minutes.

The dried films, on a white background, are assessed visually for their degree of yellowing, as follows:

Table 6 Discolouration Comparison colour. without additive Yellow 0.5% of stabiliser 4 White with very slight yellow tinge The same results are obtained if instead of dimethylformamide other solvents, such as, for example, an ethylene carbonate-water (:20) mixture, are used.

EXAMPLE 22 Table 7 Ml/2 l60 g at 230C in g/10 minutes Stabiliser No. As 1st 2nd 3rd (concentration) supplied extrusion extrusion extrusion No stabiliser 2.50 11.3 21 5 35.0 2 (0.1%) 250 2.84 3.22 6.42 9 (0.0571) As can be seen from the values in Table 7, stabiliser No. 2 according to the invention, not only by itself but also in. combination with a conventional phenolic antioxidant, improves the stability of the polymer to processlng.

y 21 EXAMPLE 23 Stabilisation of high molecular low pressure polyethylene against crosslinking during processing 0.05% of stabiliser 4 are homogeneously mixed with the polyethylene powder (molecule weight 250,000) and the mixture is regranulated in a singlescrew extruder at a maximum of 200C, and 100 revolutions per minute. For comparison. granules without the addition of stabiliser 4 are manufactured in the same way. The melt index (MI) was determined on the starting material and on the extruder granules.

The oxidative damage to the polymer material by heat exposure during extrusion causes'crosslinking of the polymer and manifests itself in a greatly increased viscosity of the polymer melt and hence a greatly re.- duced melt index. (Table 8).

Table 8 MI (10 kg at 230C)g/10 minutes In addition to keeping the melt index constant, stabiliser 4 causes a distinct improvement in colour after regranulation as compared to the unstabilised material.

EXAMPLE 24 Stabilisation of styrene-butadiene copolymers (SBR) a. Preparation of the test specimens 100 parts of an unstabilised styrene-butadiene rubber (Synpol 1,500 emulsion SBR from Texas US. Chem. Corp.) are homogenised for 10 minutes with 0.125 part of one of the stabilisers indicated in Table 9 in a Brabender plastograph at 150C and 60 revolutions per' minute. The mixtures stabilised in this way are pressed in a sheet press at 120C for 5 minutes to give 1 mm thick sheets. The unstabilised rubber sheet which serves for comparison is prepared in the same way. b. Test The gel content determined after storage in air at elevated temperatures serves as a criterion of the protective action of the stabilisers incorporated. For this purpose, the test specimens obtained above, on aluminium supports, are kept at 100C in a circulating air oven and examined periodically (approx. every 10 ,hours) for their gel content, which is determined as follows.

Approx. 1 g of the samples is cut into pieces of size approx. 3 3Xl mm and these are dissolved overnight in 100 ml of n-hexane at room temperature. These solutions are filtered through glass wool and the gel particles retained by the glass wool are rinsed with 3 times 20 ml of n-hexane, and the filtered solutions are evaporated to dryness and dried to constant weight. The gel content of the sample is then obtained from the following calculation:

v 22 Table 9 Stabiliser No. Induction period, until a high gel (0.125%) content rapidly arises 5 N stabiliser hours 2 40 hours 4 35 hours 6 20 hours 8 20 hours What we claim is: 10 l. A compound of the formula O 1| HO 'C H Q- (Y) C0CH CCH 0-P(Z) q CH 0 R R wherein R denotes alkyl of l to 5 carbon atoms,

R; denotes hydrogen or alkyl of 1 to 5 carbon atoms, R; denotes hydrogen or methyl, Q denotes O, NH-, NHCO, OCO- or -N1-1CONI-l,

Y denotes CH or CH CH SCH Z denotes oxygen or sulfur, n denotes 0 to 4, p denotes 0 or 1, and q denotes O or 1. 2. A compound according to claim 1 wherein R, denotes methyl, isopropyl or tert-butyl, R denotes methyl, isopropyl or tert-butyl, R denotes hydrogen, Q denotes O, NH, -NHCO, -OCO- or -NHCONH,

Y denotes CH or CH CH SCH Z denotes oxygen or sulfur, n denotes 0 to 4, p denotes O or 1, and q denotes 0 or 1.

3. A compound according to claim 1 wherein R and R denote tert-butyl, R denotes hydrogen, Q denotes O, NH or NHCO. Y denotes -CH Z denotes oxygen, n denotes 0, p denotes 0 or 1, and q denotes 0 or 1. 4. A compound according to claim 1 of the formula tert-butyl CH 0 ll HO C H nNHC OCH C\ CH 0 P--(Z)q tertutyl CH 0 wherein n denotes an integer 0 to 4,

Z denotes oxygen or sulfur, and q denotes 0 or 1. 5. A compound according to claim 1 of the formula R 1 CH 2 0 CH O o H no 23 24 wherein R denotes methyl isopropyl or tert-butyl. and tert-butyl CH R denotes methyl, isopropyl or tert-butyl. 0 6. A compound according to claim 1 of the formula l' H OCH COCH C CH 0 P R1 5 CH 0 CH 0 tert-butyl 2 ll HO CnH Z- c 2 P 10. A compound according to claim 1 of the formula n CH 0 tert-butyl Z R2 2 u HO HCUCH C CH 0 P wherein R, denotes methyl isopropyl or tert-butyl i q CH 0 R denotes methyl, isopropyl or tert-butyl, t It butyl 2 Agenotes or NH and 11. A compound of the formula 11 enotes or 1 7. A compound according to claim 1 of the formula tert-butyl CH 0 H 0 C t). H0 C 2n 0 (CH scfl cocn c CH O P HO NHCOCH2-C CH20 P=O CH20 Z wherein R denotes methyl, isopropyl or tert-butyl, tertbutyl R denotes methyl, isopropyl or tert-butyl, and 8. A compound according to claim 1 of the formula denotes O to 12. A compound of the formula tert-butyl 2 tert'butyl 2 00 0 ,0 II n II n t t-butyl H 0 CH 0 tert-butyl 9. A compound according to claim 1 of the formula whe ein m d no es O or 1. 

1. A COMPOUND OF THE FORMULA
 2. A compound according to claim 1 wherein R1 denotes methyl, isopropyl or tert-butyl, R2 denotes methyl, isopropyl or tert-butyl, R3 denotes hydrogen, Q denotes -O-, -NH-, -NHCO-, -OCO- or -NHCONH-, Y denotes -CH2-or -CH2CH2SCH2-, Z denotes oxygen or sulfur, n denotes 0 to 4, p denotes 0 or 1, and q denotes 0 or
 1. 3. A compound according to claim 1 whereiN R1 and R2 denote tert-butyl, R3 denotes hydrogen, Q denotes -O-, -NH- or -NHCO-, Y denotes -CH2-, Z denotes oxygen, n denotes 0, p denotes 0 or 1, and q denotes 0 or
 1. 4. A compound according to claim 1 of the formula
 5. A compound according to claim 1 of the formula
 6. A compound according to claim 1 of the formula
 7. A compound according to claim 1 of the formula
 8. A compound according to claim 1 of the formula
 9. A compound according to claim 1 of the formula
 10. A compound according to claim 1 of the formula
 11. A compound of the formula
 12. A compound of the formula 